Clinical AI Strategy & Implementation

Where Clinical Expertise
Meets AI Architecture

25+ years architecting the clinical research systems that AI now runs on — translational platforms, clinical trials, LIMS, and data infrastructure. Now applying that domain depth to AI implementation that actually works.

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Trusted by
MD Anderson Cancer Center National Cancer Institute · NIH James P. Allison Institute SLA Pharma NCI Cancer Moonshot Initiative
About X2G Health

Bridging the Gap Between Research and AI That Actually Works

X2G Health was founded on a simple conviction: the biggest barrier to AI in healthcare isn't technology — it's the gap between what engineers build and what clinicians actually need.

Our practice is led by a Principal Solutions Architect with 25 years at MD Anderson Cancer Center building clinical research systems from the ground up — LIMS, clinical trial management, translational research platforms, data governance infrastructure. Not advising. Building. The AI work is recent, but it runs on top of two and a half decades of domain knowledge that can't be shortcut.

That means we speak both languages fluently: the clinical domain requirements and the engineering architecture. That combination is rare, and it's what X2G Health is built on.

"We don't build proof-of-concepts. We build systems that researchers and clinicians trust with their most critical workflows."
Juan F. Posadas Ruiz, MBA
Founder & Principal · X2G Health
RAG 2.0 Clinical Informatics Translational Research NLP · Computer Vision NIH / NCI Programs Biopharma
25+
Years in Clinical Informatics
36+
Institutions Served
13
Countries Reached
3
Federal NCI Programs
What We Do

End-to-End Clinical AI Services

From strategy through deployment — built for the unique demands of clinical and research environments.

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Clinical AI Architecture

Design and deploy production AI systems built for real clinical environments. Scalable architectures that integrate with existing workflows, comply with regulatory requirements, and actually get adopted.

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RAG & Knowledge Systems

Retrieval-augmented generation for clinical document processing, pathology reports, and research literature. RAG 2.0 pipelines with Qdrant, Neo4j, Docling, and Presidio for de-identification.

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Translational Research Platforms

End-to-end informatics infrastructure for multi-site clinical research — bio-sample tracking, cohort management, protocol integration, and federated data access across institutions.

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Data Pipeline Engineering

HIPAA-compliant data pipelines that transform raw clinical data into AI-ready datasets. ETL architecture, real-world evidence systems, and NLP for unstructured clinical text.

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Federal Program Informatics

NIH/NCI program support across CIMAC, PSRC, and Moonshot Initiative programs. Regulatory reporting, multi-site data harmonization, and compliance infrastructure for federally-funded research.

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Fractional CTO Services

Strategic AI leadership on a consulting basis. Ideal for biopharma startups, CROs, and academic medical centers that need senior clinical AI expertise without a full-time hire.

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Featured Work

Systems Built at Scale

Production implementations across clinical research, oncology informatics, and AI — built to work in demanding real-world environments.

Flagship · Translational Research

APOLLO Bio-Sample Tracking & Research Platform

MD Anderson Cancer Center · IDSO

Architected APOLLO from day one as the informatics home for translational research at MD Anderson under the Institute for Data Science in Oncology (IDSO). A production-grade platform integrating bio-sample tracking, clinical data, and genomics across complex multi-protocol studies — serving as the single source of truth for sample provenance, cohort management, and protocol compliance. Supports major initiatives including MOSAIC, STRIDE, and Rare Tumor programs.

Built on top of APOLLO, Artemis is a RAG 2.0 conversational intelligence layer combining Qdrant vector search, Neo4j knowledge graphs, and LLM-powered reasoning over pathology reports, biomarker data, and clinical documents — enabling researchers to query the institution's translational knowledge at the point of inquiry.

220+
Research Cohorts
13.7K+
Study Participants
120+
Active Protocols
RAG
2.0 Architecture
Computer Vision · GI Oncology

PolypCounter — Multi-Site EU Deployment

Designed and deployed a clinical-grade computer vision application for automated polyp detection and counting in GI oncology trials across multiple European sites in partnership with SLA Pharma. Integrated directly into endoscopy workflows, standardizing AI-assisted assessment across institutions with varying infrastructure and regulatory requirements.

EU
Multi-site
CV
Computer Vision
Clinical Trials · LIMS

Clinical Trial & Laboratory Information Systems

Architected and delivered multiple CTMS and LIMS implementations supporting complex oncology trials — from protocol management and regulatory submissions to specimen tracking, assay workflows, and chain-of-custody. Built to meet 21 CFR Part 11 and GCP requirements across academic medical centers and federal programs.

GCP
Compliant
21 CFR
Part 11
Pulmonology · Global Deployment

MPR Calculator — IASLC 12-Site Deployment

Built and deployed the Major Pathologic Response (MPR) Calculator for the International Association for the Study of Lung Cancer (IASLC) across 12 clinical sites worldwide. The tool standardizes MPR assessment methodology in lung cancer neoadjuvant therapy trials, enabling consistent pathological response scoring across institutions and countries.

12
Sites Worldwide
IASLC
Lung Cancer
Multi-Omics · Data Governance

Multi-Omics Data Sharing Platforms

Designed federated multi-omics data sharing infrastructure for multi-center oncology consortia — enabling genomics, proteomics, and clinical data to be harmonized and shared across institutions while maintaining data governance, patient privacy, and regulatory compliance. Supported NIH/NCI-funded programs including CIMAC and PACT under the Cancer Moonshot Initiative.

NIH
NCI Funded
Fed.
Governance
Global Reach

Where Our Software Has Worked

Clinical research platforms, AI tools, and consulting engagements spanning leading institutions across 14 countries.

36+
Institutions
34
Cities
13
Countries
Legend
United States
International
Institutional Relationships

Built Through Doing, Not Advising

Every relationship below was forged through years of production work — not client pitches.

MDA

MD Anderson Cancer Center

25+ year engagement as Principal Solutions Architect within the Institute for Data Science in Oncology (IDSO). Designed, built, and operated translational research informatics infrastructure including APOLLO, Artemis, CTMS, and LIMS systems used across active clinical research programs and federal initiatives.

Houston, Texas · IDSO
NCI

National Cancer Institute · NIH

Informatics contributor across three federal programs: CIMAC (Cancer Immune Monitoring and Analysis Centers), PSRC-PASSCODE, and PACT under the National Cancer Moonshot Initiative. Multi-site data harmonization, reporting infrastructure, and compliance systems supporting NIH-funded oncology research.

Bethesda, Maryland
SLA

SLA Pharma

Designed and deployed PolypCounter, a clinical-grade computer vision system for GI oncology trials, across multiple European clinical sites. Delivered end-to-end: from algorithm development through regulatory-compliant site deployment and staff training across institutions and languages.

European Multi-Site
IASLC

International Assoc. for the Study of Lung Cancer

Built and deployed the MPR Calculator across 12 IASLC clinical sites worldwide, standardizing Major Pathologic Response assessment in neoadjuvant lung cancer trials. A tool developed in close collaboration with clinical investigators to address a real unmet need in pathological response scoring.

12 Sites · Global
Let's Work Together

Ready to Build Something That Actually Works?

Whether you're a cancer center, biopharma, CRO, or NIH-funded program — if you're serious about clinical AI implementation, let's talk.

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Houston, Texas · Remote Available
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English · Spanish · Portuguese (reading)
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Accepting engagements starting September 2025